Dimethylethanolamine or DMAE is best known as an oral cognitive supplement. Dr. Perricone, dermatologist to celebrities, claims that it has a great effect on skin. His topical creams include DMAE and are said to aid in tightening the muscles that keep the skin looking healthy. It is also claimed to diminish the appearance of wrinkles, crows feet, and sagging skin.
Dimethylaminoethanol (DMAE) is an antioxidant and considered by Dr. Perricone as a membrane stabilizer. According to Dr. Perricone, when DMAE is taken orally or applied topically, it helps to firm, smoothe, and brighten skin. It also enhances the effects of other antioxidants like alpha lipoic acid and Vitamin C ester.
"Dimethylaminoethanol is related to choline and may be a biochemical precursor to the neurotransmitter acetylcholine, although this conclusion has been disputed. It is believed that dimethylaminoethanol is methylated to produce choline in the brain. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood–brain barrier."